Assisted Hatching IVF: Does It Really Improve Success?

Fertility treatments can be overwhelming, especially when new phrases like “assisted hatching” pop up. For anyone considering in vitro fertilization (IVF), it’s helpful to understand what assisted hatching is, why clinics use it, and whether it really improves the chances of getting pregnant.

It’s empowering to know how the process works and how it might fit into specific fertility goals. Below is an easy-to-digest overview of assisted hatching IVF, including some scientific insights, possible pros and cons, and practical tips for deciding if this technique could be right for you.

What is the assisted hatching technique?

Assisted hatching essentially means creating a tiny opening in the outer layer of an embryo (the zona pellucida). This outer “shell” protects the embryo while it’s still in the very early stages. Normally, an embryo will hatch on its own during IVF and in the body during spontaneous conception — popping out of that shell before attaching to the uterine lining. But sometimes, if the shell is extra thick or tough, it can be harder for the embryo to hatch naturally.

With assisted hatching, a trained embryologist uses tools like a laser, a chemical solution, or a delicate instrument to make the shell thinner or to create a small hole. This little tweak is designed to help the embryo slip out more easily, hopefully leading to a better chance of implanting in the uterus.

The American Society for Reproductive Medicine (ASRM) explains that if the embryo can free itself without too much trouble, it might have a higher chance of successfully attaching to the uterine lining and continuing to grow.

Is assisted hatching done before freezing?

Different clinics have different approaches, so there’s no one-size-fits-all answer. Some do assisted hatching on the embryo before freezing, thinking it’ll be ready to go once it’s thawed. Others wait until after thawing to be sure that the embryo’s shell is opened right before the transfer. A few clinics might do it at the blastocyst stage or on embryos that have already been frozen and are being thawed for transfer.

• Assisted hatching before freezing: This approach is meant to get the embryo “prepped” so that once it’s thawed, it can hopefully implant more easily.
• Assisted hatching after thawing: Some fertility specialists prefer to wait and make that little opening right before transfer, so the embryo’s shell is as freshly opened as possible.

Because every clinic does things slightly differently, it’s a good idea to chat with a fertility specialist to find out their method, success rates, and why they prefer their specific timing.

How long does it take for an embryo to implant with assisted hatching?

Typically, embryos implant in the uterus somewhere around 6 to 10 days after fertilization, and assisted hatching doesn’t really change that overall timeframe. Some experts hope that by thinning or opening the shell, the embryo may implant a bit sooner, but there’s no strict schedule that applies to everybody. Hormones, the health of the uterus, and embryo quality all play a part.

Usually, fertility clinics advise a two-week wait after the transfer — often called the “two-week wait” — before taking a pregnancy test. This waiting period can feel like an eternity, but it’s necessary because everyone’s body needs time to show reliable results.

When is assisted hatching recommended?

Not every IVF cycle automatically includes assisted hatching. It’s often recommended for people who might benefit most from a little extra help “breaking out” of the shell. A few scenarios where assisted hatching could be suggested include:

• Repeated IVF failures: If you’ve already tried multiple IVF cycles without success, assisted hatching may be worth a shot to see if giving the embryo a head start helps.
• Advanced maternal age: People over 35 or 37 sometimes get this recommendation because egg quality changes over time, and tougher shells can make it harder for the embryo to hatch on its own.
• Thick zona pellucida: If the embryology team notices that your embryos have a noticeably thicker or harder outer layer, assisted hatching might help.
• Poor embryo quality: Embryos that grow more slowly or show certain structural issues could have a tougher time with the natural hatching process.

Since every person’s situation is different, it’s important to talk through the potential benefits, risks, and limitations with a fertility expert.

How successful is IVF with assisted hatching?

Many factors go into IVF success, including the age of the patient, the quality of the embryo, and the reasons behind infertility in the first place. Research published in Reproductive Biology and Endocrinology points out that assisted hatching may improve implantation rates for certain groups, like those who’ve had more than one failed IVF cycle or are older than 37.

That said, not all studies agree on how big a boost assisted hatching gives. Some findings show mixed results, and experts say more large-scale research is needed to figure out exactly who benefits the most. Many clinics, though, believe that for the right people, assisted hatching can slightly raise the odds of a successful pregnancy.

Keep in mind that success depends on your overall fertility profile. Things like your age, genes, embryo quality, and underlying health conditions all matter. Plus, each clinic has its own track record, so it’s totally fair to ask about success rates and to have open, candid conversations with your doctors.

What are the cons of assisted hatching?

Sure, assisted hatching sounds like a promising extra step, but it’s important to be aware of the potential downsides:

• Damage to the embryo: Even with the greatest care, making a hole or thinning the shell can risk harming the embryo.
• Cost: IVF is already expensive, and assisted hatching adds another charge. Finding out whether it’s truly beneficial for your situation helps you decide if it’s worth the extra money.
• Possible increase in monozygotic twins: Some research hints that assisted hatching might slightly up the chance of identical twins if a single embryo splits. This isn’t a guarantee, but it’s something to be aware of.
• Mixed evidence of effectiveness: It doesn’t always lead to higher success rates. Younger people with good-quality embryos might not see a big difference, so a doctor might suggest skipping this add-on.

How much does assisted hatching cost?

Assisted hatching isn’t free. It’s an extra procedure on top of standard IVF expenses, and the price tag can vary a lot depending on where you live and which clinic you’re working with. Think anywhere from $500 to $1,500 for each IVF cycle. Some clinics offer package deals that bundle assisted hatching with other services, while others itemize everything.

Physical and emotional health considerations

Dealing with fertility treatments can be both physically and emotionally challenging. Adding another procedure like assisted hatching can come with extra questions and worries. Stress, anxiety, and even depression are common, so it’s important to keep mental health in mind. Leaning on a strong support system — partners, friends, family, or mental health pros — can make the journey feel less lonely.

It also helps to keep up with healthy habits, like balanced eating, gentle exercise, mindfulness, and stress-reduction strategies. Ongoing research suggests that chronic stress might affect hormone levels, and that could impact overall fertility. So, looking after your emotional well-being could be just as important as the medical steps.

Assisted hatching and your IVF plans

When it comes to IVF, there’s a list of potential tests, techniques, and add-ons to consider. Assisted hatching is just one more decision. Making the best call means staying informed, being open about your questions with a fertility specialist, and going with reputable research. Experts are still debating how effective assisted hatching really is, but there’s proof it can be helpful for certain people — like those who’ve had repeated IVF failures or who face specific embryo challenges.

No single treatment route can promise a 100% success rate, but a good medical team, a thorough evaluation of your fertility, and access to advanced methods can all work together in your favor. Whether assisted hatching is part of your plan or not, the main goal stays the same: creating the most supportive environment for an embryo to implant, develop, and ultimately lead to a healthy pregnancy.

Tassia O'Callaghan is an experienced content writer and strategist, having written about a vast range of topics from chemical regulations to parenting, for brands like Peanut App Ltd, Scary Mommy, Tally Workspace, and Office Christmas. She's an advocate for realistic sustainable living, supporting small businesses (author of A-Z of Marketing for Small Businesses), and equity across all walks of life. Follow her on LinkedIn or TikTok, or see more of her work on Authory or her website.